Abstract
The polyamines putrescine, spermidine and spermine are ubiquitously expressed cations that are essential for normal cellular function. AMD1 is a key, rate limiting enzyme that drives the conversion of putrescine to spermidine and spermine and thus can change the ratios of the three polyamines. The polyamines, specifically spermine, show a dramatic reduction in levels in aged skin yet their role within the skin is not well understood. The purpose of this study was to examine the role of polyamines in skin barrier formation and wound healing.
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