Abstract
Abiraterone, a CYP17 enzyme inhibitor, blocks the synthesis of androgens but causes the hyperaldosteronism that requires long term steroid use. The long term steroid use may cause serious side effects. LAE001 is a novel dual inhibitor of CYP17 and CYP11B2 (aldosterone synthase) that blocks both androgen and aldosterone synthesis. This study provided clinical evidences that LAE001 monotherapy is a safe medicine that can achieve androgen inhibition without hyperaldosteronism in patients with mCRPC.
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Schedule a callMore From: Annals of oncology : official journal of the European Society for Medical Oncology
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