Abstract
CD200R is an immune receptor of the IgG family that is primarily expressed on cells of the myeloid lineage and was recently identified as a marker for Th2 biology (Blom et al 2017). In vivo studies with knockout mice of either the receptor or its ligand, CD200, have demonstrated that it is an inhibitory receptor capable of negatively regulating immune responses. Previous work using agonistic antibodies to mouse CD200R showed inhibition of mast cell activation in vitro and in vivo (Cherwinski et al 2005) as well as efficacy in multiple preclinical models of autoimmune diseases.
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