Abstract
Substance P is one of the neurotransmitters mainly involved in neurogenic inflammation on cutaneous level, a key point in the pathogenesis of inflammatory skin disorders such atopic dermatitis (AD), associated pruritus, and sensitive skin. In vitro models evaluated the effect of the original biological extract of Aquaphilus dolomiae E0 (Ad-E0) on cutaneous neurogenic inflammation. Ad-E0 significantly inhibited SP-stimulated release of IL-1β and TNF-α from normal human epidermal keratinocytes; significantly and dose-dependently inhibited SP-stimulated activation of human mast cells; significantly inhibited veratridine-stimulated release of SP from human sensory neurons; modulated expression of genes involved in lipid synthesis, innate immunity, corneocyte scaffolding and epidermal differentiation in a histamine-sensitized reconstructed human epidermis model; and, when applied topically to ex vivo human explants, inhibited IL-8 and histamine release. Topically applied Ad-E0, once formulated, may improve neuro-inflammation in patients with inflammatory skin disorders.
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