Abstract
The degree of elevation of B-type natriuretic peptide (BNP) correlates with cardiac filling pressures, the extent of left ventricular dysfunction, and worse outcomes in patients with heart failure. However, in cardiac transplant recipients, BNP levels correlate only modestly with rejection. We hypothesize that a within-individual change in BNP over time would be more helpful than absolute BNP in detecting rejection of ISHLT grade 2R or higher in pediatric cardiac transplant (tx) recipients.
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