596 Elucidating the role of Circular RNA circGLIS3 in human skin wound healing

Abstract

Circular RNAs (circRNAs) are a novel class of RNA with combined 3’ and 5’ ends. An increasing number of circRNAs have been shown to play important biological roles; however, their expression and function in human skin wound healing remain largely elusive. We have profiled circRNA expression in human skin and wound tissues as well as in keratinocytes and fibroblasts isolated from these tissue samples. We found increased fibroblast expression of a circRNA derived from the GLIS3 gene (circGLIS3) in the wounds compared to the matched skin.