Abstract
Dysregulation of miRNAs is involved in osteosarcoma (OS). Here, we demonstrate that miR-199 is decreased in specimens of OS patients with a poor chemoresponse compared to those with a good chemoresponse. In addition, our clinical data show that decreased miR-199 was associated with poor survival in OS patients. Overexpression of miR-199 inhibited cell growth and chemoresistance. In contrast, inhibition ofmiR-199 or overexpression of target genes stimulated OS cell growth and chemoresistance both in vitro and in vivo. Taken together, these findings suggest that miR-199 is a tumor suppressor miRNA and induction of miR-199 is a potential strategy to inhibit OS progression.
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