Abstract
Radiotherapy (RT) is a common cancer treatment but often results in an unintended injury to overlying skin and contributes to impaired wound healing. Skin fibroblasts (FBs) play critical roles in wound repair. We investigated the long-term effects of RT on FB functions to understand better the pathological mechanisms of adverse skin reactions to RT. We collected tissue biopsies from non-irradiated (RT-) and irradiated skin (RT+) of breast cancer patients who received RT 1-12 years ago. We found that ex vivo wound healing and FB motility were significantly reduced in the RT+ skin compared to the paired RT- skin.
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