591 Dual targeting mTOR and autophagy by fisetin alleviates psoriasis-like responses induced by TNF-α and IL-17A in vitro and imiquimod-induced dermatitis in vivo

Abstract

Recently, the central mTOR pathway has emerged as a clinically relevant player in the pathogenesis of psoriasis. Our previous study has shown that fisetin, a dietary polyphenol, possesses prodifferentiation and mTOR inhibitory properties, and suppresses psoriasis-like responses in vitro. However, the effects of fisetin on psoriasis in vivo and the underlying mechanisms are unclear. Here, we evaluated fisetin's effects on cytokines(IL-6/22 and TNF-A/IL-17A) and anti-CD3/CD28 stimulated keratinocytes(HEKa) and CD4+T cells compared to rapamycin, a known inhibitor of mTOR.