Abstract
Tumor necrosis factor-alpha (TNF-α) plays a significant role in the conditioning related toxicities and development of acute GvHD (aGvHD). In this study, we sought to examine if specific polymorphisms in TNF pathway genes were associated with risk of aGvHD. Single nucleotide polymorphisms (SNPs) in TNF-α; and TNF receptor superfamily member 1A (TNFRSF1A) and 1B (TNFRSF1B) were investigated; we selected SNPs with minor allele frequency of ≥10% (13 in all) and TNF-α d microsatellite. In a multi-institutional trial, 180 eligible patients (mean age 10 y, median 11, range 6 m-20 y) were prospectively evaluated for clinical outcomes after 6/6 matched unrelated donor marrow transplants.
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