Abstract
Malignant gliomas still have a dismal prognosis despite advances in neurosurgical resection and adjuvant radio- and chemotherapy. One major reason is their infiltrative growth pattern with single tumor cells migrating distantly from the solid tumor mass and infiltrating normal brain tissue. These cells are responsible for recurrent tumors near the resection cavity or even far away from it and should therefore be the main target cell population for new therapeutic interventions.
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