#59 Efficacy of Oral Cryotherapy in the Prevention of Oral Mucositis during high dose chemotherapy infusion for children with autologous stem cell transplant

Abstract

Abstract Background Oral mucositis is one of the most common and distressing side effects of cancer therapy, especially high dose chemotherapy. This study aims to evaluate the effectiveness of oral cryotherapy in prevention oral mucositis in children with autologous stem cell transplant Method A prospective study was carried out in children receiving autologous stem cell transplant since December, 2019 to December, 2021 at Hue Central hospital in Vietnam. All patient were received oral cryotherapy during chemotherapeutic agents infusion. The way to measure oral mucositis with specific scale based on WHO grading system for oral mucositis. Data was abstracted from patient medical records and analyzed in SPSS v.18.0 (IBM Corp., Armonk, NY, USA). Results From December, 2019 to December, 2021, a total of 20 patients receiving autologous stem cell transplantation, with a median age of 3.75 years (range: 2.5 years to 8 years). Of these patients, 18 patients (90%) was diagnosed high risk neuroblastoma and treated with regimen conditioning: Busulfan and melphalan; 1 patient (5%) was diagnosed relapsed Burkitt lymphoma and used high dose chemotherapy with carmustine, etoposide, cytarabine and melphalan; 1 patient was diagnosed metastatic retinoblastoma and treated with carboplatin, etoposide and thiotepa. During oral cryotherapy, all the patients tolerated well and had no side effect. 15% patients did not have any signs of oral mucositis, 85% of patients had oral mucositis, in which grade I mucositis accounted for 70% and grade II mucositis accounted for 15%. The median time for oral mucositis recovery was 5 days (range: 4 days to 11 days). Conclusion Oral cryotherapy is effective in preventing oral mucositis in patients undergoing high dose chemotherapy for the autologous stem cell transplantation. However, we need to implement and evaluate in the larger number of patients.