Abstract
There are several testosterone replacement therapy (TRT) methods for late-onset hypogonadism (LOH), including oral, injection, trans-dermal, etc. However, only TRT with injection (testosterone enanthate) or short-acting ointment (Glowmin: GL) are available for LOH patients in Japan. Our previous report revealed that 3 mg of a short-acting testosterone ointment elevated serum testosterone levels within the physiological range for 4 to 6 hours. The aim of this study was to clarify clinical efficacy and safety of GL once every morning, which would enhance a circadian rhythm of testosterone. Each Institutional Review Board (IRB) approved this prospective clinical study and informed consents had been obtained from 61 LOH patients. These 61 LOH patients received 3 mg of GL once daily in the morning on scrotal skin and the clinical efficacy of GL were estimated by aging male symptoms (AMS) score at 4, 12 and 24 weeks after GL administration. Blood sampling tests including serum hormone levels, hemoglobin, liver and real functions, lipids, blood sugar and prostate specific antigen were compared before and 12, 24 weeks after GL treatment.
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