Abstract
Psoriasis is a dermatosis characterized by keratinocyte hyperproliferation, and abnormal epidermal differentiation. Clinical studies have shown that supplementation of the diet with omega-3 fatty acids could improve the symptoms of psoriatic patients. However, the mechanisms involved are still poorly understood.The aim of this study was to investigate the effects of α-linolenic acid (ALA) on the keratinocyte proliferation and differentiation of a psoriatic skin model. Healthy (HS) and psoriatic skin substitutes (PS) were produced according to the self-assembly method of tissue engineering, using culture media supplemented with 10 μM ALA.
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