Abstract
In the non-viral gene delivery system, plasma membrane is one of the barriers inhibited efficient gene expression. Previously, we developed a viral-like delivery system, transferrin-modified liposomes (Tf-L) equipped with pH-sensitive fusogenic peptide GALA (WEAALAEALAEALAEHLAEALAEALEALAA). Tf-L encapsulating aqueous marker rhodamine were internalized via Tf receptor-mediated endocytosis into human leukemia cells K562. The efficient release of rhodamine into the cytosol was induced by not addition of a free GALA to Tf-L-containing medium but equipment of Tf-L with cholesterylated GALA (Chol-GALA). Thus, GALA must be present on the surface of liposomes to exert its function.
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