585 The effect of topical 5-azacytidine in irritant and allergic contact dermatitis

Abstract

DNA methylation is one of major epigenetic mechanisms by which regulate a panel of gene expressions. An old but a revisiting compound, 5-azacytidine, is a pyrimidine nucleoside analog of cytidine that can inhibit DNA methyltransferase, induce cell differentiation, and has direct cytotoxicity on abnormal bone marrow hematopoietic cells. Thus, systemic administration of 5-azacytidine has been approved for the treatment of myelodysplastic syndrome and acute myeloid leukemia. However, the effect of topical 5-azacytidine on skin inflammation is largely unknown.