583P A prospective observational study to see the effect of pelvic radiation on hematopoetic system

Abstract

Background Radiotherapy may induce irreversible damage on healthy tissues surrounding the tumor. It has been reported that the majority of patients receiving pelvic radiation therapy show early or late tissue reactions. Haematopoetic system affect more in some special siter related to blood cell production. Methods After fulfillment of inclusion and exclusion criteria patient was enrolled to the study by giving an ID no. A complete blood profile was done before starting Radiotherapy. As well as a clinical evaluation according to RTOG Guideline. After this pelvic Radiation was started and C.B.C was done and recorded weekly. Main outcome measure(s): Age, sex, occupational status, performance status, Hemoglobin, TC of WBC diffent follow-up. Results More than one third (36.0%) of the patients received pelvic radiation were in 5th decade and the mean(±SD) age was 49.9±10.5 years. Male to female ratio was 1:1.6. Before treatment the mean hemoglobin % was 11.0±1.1 mg/dl, during 2nd week of treatment it was 10.7±1.0 mg/dl, during 4th week of treatment it 10.37±0.7 mg/dl. Before treatment the mean TC of WBC was found 11107.4±13481.4/mm3, during 2nd week of treatment the mean TC of WBC was found 8204±3006.6 mm3, during 2nd week of treatment the mean TC of WBC was found 7550.6± 2514.6 mm3. Hemoglobin level and TC of WBC decline in subsequent follow-up but serum creatinine level increased in subsequent follow-up. Conclusions Hematopoetic system is significantly correlated in patients undergoing pelvic Radiation. Every change of blood count in weekly basis help to predict the necessity of taking effective measure. Legal entity responsible for the study Radiotherapy Department, Dhaka Medical College Hospital Funding Dhaka Medical College and Hospital Disclosure All authors have declared no conflicts of interest.