Abstract

Cellular senescence is an irreversible growth arrest caused by oxidative stress and DNA damage and ultraviolet radiation mediated cellular damage is responsible for skin photoaging. The Type 17 collagen (COL17A1) expressed in epithelial hemidesmosomes plays a crucial role in maintaining hair follicle stem cells. Apocynin, (1-(4-Hydroxy-3-methoxyphenyl)ethan-1-one)) is a chemical inducer of Collagen 17A1 which promotes the Collagen 17A1 protein synthesis. Our unpublished data showed that klotho mutant (kl/kl) mice, which is a premature aging model, display increased senescence associated-β-galactosidase (Sa-β-Gal) activity, p16 and phosphorylated histone H2AX (γH2AX) expression along with deceased Collagen 17A1 expression.

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