580-P: Cardiovascular Autonomic Neuropathy Is Associated with Carotid Intima-Media Thickness and Arterial Stiffness in Patients with Type 2 Diabetes

Abstract

Cardiac autonomic neuropathy (CAN) is a frequent but underdiagnosed complication of diabetes mellitus. CAN represents a significant cause of morbidity and mortality in patients with diabetes and is associated with a high risk of cardiac arrhythmia and sudden death. The aim of this study is to evaluate the association between CAN and carotid intima-media thickness (CIMT) and arterial stiffness in patients with type 2 diabetes mellitus (T2DM). CAN, CIMT, ankle-brachial index (ABI) and pulse wave velocity (PWV) were evaluated in a cross-sectional sample of 321 patients (147 men and 174 women) with T2DM. CAN was assessed by Ewing’s method which employs five non-invasive tests of autonomic function. Among 321 patients, CAN was found in 87 patients (27%). Compared with the patients without CAN, those with CAN were significantly older and had significantly longer duration of diabetes, lower glomerular filtration rate, higher hs-CRP, mean CIMT, PWV, and ABI. The CAN scores correlated positively with mean CIMT and PWV (P<0.05). Using multivariate regression analysis, CAN score independently predicted mean CIMT in patients with T2DM after adjustment for age and DM duration. In conclusion, CAN was associated CIMT and increased arterial stiffness in patients with T2DM. CAN might be associate with the development of cardiovascular disease through CIMT and arterial stiffness in T2DM. Disclosure T. Sohn: None.