Abstract
RNA viruses are a known risk factor for obliterative bronchiolitis (OB), the major cause of mortality in lung transplantation. Using a murine heterotopic tracheal transplant model (HTT) of obliterative airway disease (OAD), we studied the role of polyinosinic acid: polycytosinic acid (polyI:C), a synthetic RNA polymer in the induction of OAD and abrogation of allograft tolerance induced by CD154 costimulation blockade
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