Abstract
Encapsulation of chemotherapeutic agents within biodegradable nanoparticles (NP) allows for gradual drug release from the polylactic acid core. Bioadhesive, degradable NPs can be retained at the site of administration, maximizing local effects while minimizing systemic side effects. Our bioadhesive NP (BNP) loaded with chemotherapy have previously been proven efficacious in the treatment of murine PDVC57 squamous cell carcinoma (SCC) tumors, with increased intratumoral (i.t.) retention of the active agent.
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