Abstract
Background: Hypoxia-inducible factor (HIF)-2α is a transcription factor that is an oncogenic driver in clear cell renal cell carcinoma (ccRCC). The posttranslational regulation of the HIF-2α protein is oxygen-dependent and, in hypoxic or pseudohypoxic conditions, results in the stabilization of HIF-2α and downstream transcription of tumor-inducing genes. HIF-2α inhibition has been shown to mitigate tumor growth in ccRCC cases with mutation or dysregulation of the von Hippel-Lindau tumor suppressor gene.
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