58 (PB-058) Poster - Breast cancer in elderly patients in a Venezuelan breast center. How we manage the axilla

Abstract

Objective: Axillary management in elderly patients with early breast cancer and clinically negative axillary nodes is controversial. This study aimed to evaluate clinico-histopathological and survival data in breast cancer patients aged 80 years or older with a negative axillary clinical and ultrasound examination not undergoing axillary lymph node investigation Patients and Method: A retrospective study of 36 patients who met the following inclusion criteria: aged 80 years or more, with a diagnosis of early breast cancer and clinically and ultrasound node negative breast cancer, and in a state of complete physical, mental well-being. The patients were treated surgically without axillary dissection. Clinico-histopathological, treatment and survival characteristics were evaluated. Results: A total of 36 patients were studied with an average age of 83.5 years (range, 80–91 years), and a median follow-up of 39.7 months (range: 0.5–168 months). Of these, 1 patient had bilateral breast cancer. Most patients were treated with partial mastectomy (64.9%). Almost all of the patients received adjuvant hormonal therapy (91.7%), almost one third received adjuvant radiotherapy (30.6%). Infiltrating ductal carcinoma represented 62% of the total. Average tumor size of 17.5 mm (range, 2– 50 mm). The most frequent molecular subtype was luminal A (54.1%). 8.3% of the patients had a relapse, none in axilla. Disease free survival was found to be a mean of 141.7 months, while five-year disease-free survival rate was 80.9%. The overall survival average time was 95.5months, while the five-year overall survival rate was 57%.Table 1:Clinical and Histopathological characteristicsAge (years) N = 36 (1 bilateral)80–8424 (66.7)85–9112 (33.3)Media (STD)83.5 (0.49)Tumor characteristicsTumor size (mm) N = 37≤2029 (78.4)<20 ≤ 508 (21.6)Media (STD) (range)17.5(1.52) (5–50)Histological type N = 37IDC23 (62.2)ILC4 (10.8)Others10 (27)Molecular Subtypes N = 37Luminal A20 (54.1)Luminal B10 (27)Luminal B-H5 (13.5)HER21 (2.7)Triple negative1 (2.7)Type of Surgery N = 37BCS24 (64.9)TM£1 patient with bilateral mastectomy13 (35.1)Treatment N = 36Adjuvant Hormonotherapy33 (91.7)Adjuvant Radiotherapy11 (30.6)Neoadjuvant Hormonotherapy9 (25)IDC: infiltrating ductal carcinoma, ILC: infiltrating lobullar carcinoma, Others: muninous carcinoma, papillary carcinoma, cribiform carcinoma, ductal carcinoma in situ. BCS: breast conservative surgery. TM: Total mastectomy.£ 1 patient with bilateral mastectomy Open table in a new tab IDC: infiltrating ductal carcinoma, ILC: infiltrating lobullar carcinoma, Others: muninous carcinoma, papillary carcinoma, cribiform carcinoma, ductal carcinoma in situ. BCS: breast conservative surgery. TM: Total mastectomy. Conclusion: Results from the present investigation suggest that axillary lymph node biopsy could be omitted in women 80 years or older with clinically node negative breast cancer treated with breast surgery and adjuvant therapy. No conflict of interest.