577P Impact of homologous recombination deficiency (HRD) on outcomes with intraperitoneal (IP) and intravenous (IV) chemotherapy in ovarian cancer: Analyses from the translational iPocc study (TriPocc)

S.T Wijaya,K Fujiwara,R.Y-J Huang,H Fujiwara,N.Y.L Ngoi,K Hasegawa,A Yabuno,Y-H Jan,T Hirasawa,T.Z Tan,M Yasuda,K Takehara,S-J Chen,D.S Tan,H Nakazawa

doi:10.1016/j.annonc.2022.07.705

577P Impact of homologous recombination deficiency (HRD) on outcomes with intraperitoneal (IP) and intravenous (IV) chemotherapy in ovarian cancer: Analyses from the translational iPocc study (TriPocc)

S.T Wijaya, K Fujiwara + Show 13 more

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https://doi.org/10.1016/j.annonc.2022.07.705

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Journal: Annals of oncology : official journal of the European Society for Medical Oncology	Publication Date: Sep 1, 2022
License type: publisher-specific-oa

#Intravenous Chemotherapy #Ovarian Cancer + Show 8 more

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Abstract

The iPocc randomised multicentre international study reported improved progression-free survival (PFS) but not overall survival (OS) with IP carboplatin and IV paclitaxel vs IV chemotherapy (chemo) in patients (pts) with epithelial ovarian, fallopian tube or primary peritoneal cancer. Previous studies suggested that pts with BRCA-deficient tumours may benefit from IP chemo. We conducted a non-prespecified analysis of the prognostic and predictive value of HRD in tissue samples retrospectively obtained from iPocc trial pts.

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