Abstract
Excessive release of reactive oxygen species (ROS) during acute skin injury has detrimental effects on wound healing. Since natural melanin is an efficient scavenger of radical species, we hypothesized that a topical treatment consisting of synthetic melanin nanoparticles (SMNP) would benefit the healing process. We utilized the mouse chemical skin injury model to test our hypothesis, using nitrogen mustard (NM) for injury induction. Topical treatment with SMNP resulted in significantly improved wound healing as evidenced by the rate of wound area reduction (p=0.006 at day 3, n=17), decreased edema (p=0.003 at day 2, n=9-10), and time of eschar detachment compared to the vehicle group (p=0.005, n=9-10).
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