575P - Adjuvant Chemotherapy and Overall Survival in High Risk Stage Ii Colon Cancer

Abstract

ABSTRACT Aim: Patients with stage II colon cancer are considered high risk in case of pathological T4 (pT4), poor or undifferentiated grade, emergency surgery, Methods: All patients with high risk stage II colon cancer diagnosed in the area of the Eindhoven Cancer Registry between 2008-2012 were included. Vascular invasion was not included. Multivariable logistic regression was used to assess the association between high risk factors and CT administration. 3-year OS according to CT was based on Kaplan-Meier curves and Cox regression was used to discriminate the independent effect of CT on the risk of death. A subsample was created using propensity score matching (PSM) in which patients who did not receive CT were matched to patients who did. Results: 922 patients were identified of whom 151 (16%) received CT. In multivariable analysis, patients were more likely to receive CT in case of a pT4 tumor (n = 188) (pT4 vs. pT3 30 vs. 11%, OR 4.82, 95% CI 3.04-7.65), Conclusions: Most high risk factors were associated with increased use of CT, although the absolute proportion of CT given was low. In this observational study CT receipt was associated with improved OS. Future studies should focus on how quality of life is affected by CT and what influence this has on choice of treatment. Disclosure: All authors have declared no conflicts of interest.