575 High expression of cell adhesion molecule 1 is a predictive unfavorable prognostic factor in patients with mycosis fungoides

Abstract

Cell adhesion molecule 1 (CADM1) was first identified as a tumor suppressor gene in a non-small cell lung cancer, and has been recognized as a favorable factor in malignant solid. On the other hand, expression of CADM1 is highly upregulated in adult T-cell leukemia/lymphoma tumor cells, leading to massive tumor formation. Therefore, it is assumed that a high expression of CADM1 in T-lymphoma cells might aggressively promote tumor development of malignant T cell lymphoma. Mycosis fungoides(MF) is characterized by epidermotropic skin infiltration of atypical T lymphocytes, however, it remains unclear whether CADM1 affects the prognosis of MF. To clarify this issue, we analyzed the relationship between CADM1 expression and the prognosis of MF. Fifty patients with MF were enrolled in this study. First, we confirmed CADM1 expression in tumor cell of MF by immunohistological technique. CADM1 expression increased in accordance with advanced tumor stage of WHO-EORTC classification. The overall survival rate was significantly lower in the CADM1 high-expression group compared with the low-expression group according to Kaplan-Meier survival analyses. Furthermore, multivariate analyses using a Cox proportional hazards model indicated that overall survival rates for the high CADM1 expression group was significantly lower than those for the low-expression group. These results indicated that there is a correlation between the degree of CADM1 expression and the progression tumors in MF. These results also demonstrated that CAMD1 expression is an independent prognostic factor for MF.