Abstract
Leptin is an adipokine with a key role in metabolism and satiety. It has also been suggested to have a pro-inflammatory and pro-thrombotic effect. Leptin levels are increased in normal pregnancy, and leptin levels have been linked to various pregnancy complications, including gestational diabetes, intrauterine growth restriction and preeclampsia. We sought to characterize methylation patterns in the leptin gene in normal early pregnancy and preeclamptic pregnancies.
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