573 Obstructive Sleep Apnea and Total Sleep Duration is Associated With Problems with Physical Function Mobility in Children

Abstract

Abstract Introduction To identify the effect of Obstructive Sleep Apnea (OSA) and sleep duration on problems with health-related quality of life (HR-QoL) in children. Methods Children ages 8–18 years visiting sleep laboratory from 07/2019 to 01/2020 for overnight PSG participated in the study. Controls seen during 01/2020-02/2020 for issues other than sleep disturbance were recruited from the primary care pediatric clinics. HR-QoL was assessed by PROMIS V1.0 questionnaires. Statistical analysis was conducted using R 3.6.0. Results 122 children were studied: 64 males (52.4%).Twenty-nine(29.2%) had mild OSA, 8 (8.1%) moderate OSA, 17 (17.1%) severe OSA,46 (46.4%) were diagnosed with No-OSA and 22 (18.0%) were controls. Patients visiting the sleep laboratory had lower physical function mobility compared to controls (p=0.004). With increasing severity of OSA, there was a step wise decrease in physical function mobility (p=0.01). Correlation analysis suggested that physical function mobility was positively associated with total sleep duration (p=0.02) and negatively associated with apnea hypopnea index (p=0.01). Symptoms of anxiety in children was positively associated with number of arousals (p=0.04). Age was positively associated with fatigue (p=0.02) and negatively associated with deep sleep (p<0.001). Regression analysis confirmed that physical function mobility was associated with total sleep duration (p=0.04) and AHI (p=0.02) after controlling for age, gender and number of arousals. Conclusion We found interrupted sleep associated with symptoms of anxiety. OSA and reduced sleep duration are associated with problems with physical function mobility after adjusting for age, gender and number of arousals. Support (if any) None