Abstract
Introduction. Intrauterine growth restriction (IUGR) due to the placental insufficiency is associated with a high morbidity and mortality for which there is no effective therapy. Various growth factors have been suggested to be essential for normal placental function and fetal growth. Among these is insulin like growth factor-1 (IGF-1) which in transgenic knockout mice has proven to result in IUGR. Exogenous IGF-1 protein administration has been ineffective in correcting IUGR. We hypothesize that intraplacental gene transfer will result in sustained high levels of transgene expression and may be more effective in correcting IUGR. In order to test our hypothesis we employed a naturally occurring model of placental insufficiency in the New Zealand Rabbit using intraplacental gene transfer of IGF-1 to correct IUGR due to placental insufficiency.
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