57-P: HYPERTENSION AND HLA-A MISMATCHING ARE ASSOCIATED WITH RESTARTING DIALYSIS IN KIDNEY TRANSPLANTATION

Abstract

Aim The interaction of the heart with other organs is well established. In particular, several donor and recipient factors involving the heart are known to be associated with graft loss in kidney transplantation. In this retrospective single-center study, we analyzed the effect of clinical, cardiological and immunological factors on kidney transplantation outcome. The study included 245 transplanted recipients from deceased donors between 2000 and 2006. Methods In donors, age, cause of death, history of hypertension, hypotension or cardiac arrest, length of intensive care unit stay, serum creatinine levels and HLA typing were evaluated; while age, waiting time, HLA typing, antibodies sensitization and allocation were evaluated in recipients. Age donor/recipient matching and HLA mismatches were also considered. Results Cox regression analysis shows that time spent in waiting list increases the risk of restarting dialysis (OR=1.01, 95% CI=1.00-1.03; p Conclusions Our study established that both hypertension and HLA-A mismatch can affect the time of restarting dialysis in patients undergoing kidney transplantation.