57. Financial Impact of a Regional Antimicrobial Stewardship Cost Saving Initiative in a Large Integrated Healthcare System

Abstract

Abstract Background A regional antibiotic stewardship program (ASP) within a large integrated healthcare system covering two, non-academic, tertiary care medical centers and an additional six community hospitals implemented multiple interventions to optimize antimicrobial therapy and reduce unnecessary hospital costs, such as transition to extended-infusion (EI) piperacillin/tazobactam (TZP), formulary restriction of antimicrobials, and antimicrobial stewardship clinical review. The purpose of this study was to evaluate the cost savings associated with these regional ASP initiatives. Methods This was a multicenter, retrospective, observational review of regional stewardship interventions across eight inpatient medical centers in Oregon. Data was collected from January 2019 to December of 2020. Cost savings associated with reduced TZP administrations was based on the duration of therapy for each encounter in adults who received TZP for >24 hours in 2020. The regional antimicrobial restriction policy was implemented in February 2020. Cost savings attributed to antimicrobial formulary restrictions and reduction in overall days of therapy/1000 patient days (DOT) were based on EPIC costs. Results The reduction in number of administrations with implementation of EI TZP resulted in &226,420 saved in 2020. &182,837 was saved due to decreased usage of restricted antimicrobial agents. An additional &433,341 was saved for overall antimicrobial costs due to 19,775 days reduction in overall DOT/1000 patient days. Conclusion A community-based regional ASP has resulted in substantial financial impact and identified areas for future cost savings within the region. Disclosures All Authors: No reported disclosures