57 EMBED: A Pragmatic Trial of User-Centered Clinical Decision Support to Implement EMergency Department-Initiated BuprenorphinE for Opioid Use Disorder

Abstract

Emergency departments (ED) are a critical access point for individuals with opioid use disorder (OUD). Medications for OUD decrease: (1) mortality after nonfatal overdose, (2) withdrawal symptoms, (3) craving, and (4) illicit opioid use. Buprenorphine (BUP) can be safely initiated in the ED and increases retention in outpatient treatment programs. Adoption of ED-initiated BUP has been slow due to lack of physician knowledge, experience, and time. The study objective was to determine the effect of a user-friendly clinical decision support system (CDS) on rates of ED-initiated BUP in the routine emergency care of individuals with OUD. A parallel group randomized pragmatic trial was conducted in 18 EDs across 5 health care systems in the United States. The EMBED intervention is a user-centered, physician-facing CDS system integrated into the electronic health record (EHR) to facilitate ED-initiation of BUP by: (1) determining a diagnosis of OUD, (2) assessing withdrawal severity, (3) motivating patients to accept treatment, and (4) automating EHR workflow including clinical and after visit documentation, order entry, prescribing, and referral. EDs were randomly allocated to the intervention versus usual care using stratified covariate constrained randomization of clusters to arms with a ratio of 1:1. Constraining covariates included EHR vendor, patient volume, practice setting, ongoing resources for OUD patients, and proportion of attending physicians waivered to prescribe BUP. Participants included adult ED OUD patients meeting a predetermined EHR phenotype for OUD and the attending emergency physicians caring for them. Control site visits associated with attending physicians who practiced at both intervention and control sites were excluded. The primary outcome was the rate of ED-initiated BUP (administration or prescription of BUP). Implementation outcomes as compared to usual care were measured using the RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) framework. 354, 800 ED visits (166, 184 intervention and 188, 616 control) from November 2019-March 2021 were assessed for eligibility. Overall, 4, 561 OUD patients (2, 457 intervention, 2, 104 controls) under the care of 607 attending physicians (335 intervention, 272 controls) were included in the analysis. Among these patients, 33% and 36% were female and the mean age (SD) was 39.4 y (13.3) and 38.5 y (13.0) in the intervention and control groups, respectively. Though the analysis is not complete at this time, full results are forthcoming and will be available in advance of the ACEP21 Research Forum. This pragmatic trial involving patients with OUD will report the effect of a user-centered CDS system that automates EHR workflow to initiate BUP in the ED.