56P Lymph node germinal centres and B cell responses in triple-negative breast cancer

Abstract

High B cell density and low B-cell receptor evenness are predictive and prognostic in triple-negative breast cancers (TNBC). Within the lymph nodes (LNs), germinal centres (GCs) are the sites of B cell maturation and development. Recently we have shown that the formation of GCs in cancer-free (CF) LNs is associated with longer disease-free progression, particularly in TNBC with low tumour infiltrating lymphocytes (TILs). Here, we aimed to investigate the role of GC formation and characterise the B cell populations in human LNs and orthotopic in vivo models of TNBC.