#5688 CLINICAL PROFILE AND OUTCOMES OF DENGUE-INDUCED ACUTE KIDNEY INJURY (DAKI): A TERTIARY CENTRE EXPERIENCE FROM SOUTH INDIA

Abstract

Abstract Background and Aims Dengue is currently the most relevant viral infection transmitted by a mosquito bite that represents a major threat to public health worldwide. While Dengue-Associated Acute Kidney injury (DAKI) is a lethal complication, it remains as one of the least studied complications. Method This is a retrospective observational study amongst adult hospitalized Dengue patients admitted at a tertiary care hospital between January 2019 and December 2019. We estimated the prevalence of Acute Kidney Injury (AKI) using KDIGO AKIN (Acute Kidney Injury Network) criteria. Outcomes were analyzed during the time of discharge. Results Out of the 1550 hospitalized patients, majority of the patients were males – 1005 (64.9%). Most common age group was between 20 to 40 years. 85 (5.48%) of the total study patients developed DAKI. Older age groups were found to be more at risk for concurrent bacterial infections and higher mortality rate. Most patients had stage 1 AKI (70.1%). Overall mortality in patients with AKI was 20.3% and 80.5% in those requiring dialysis. The incidence of DAKI risk was increased by as much as 4.5-fold in the presence of hemoconcentration (or hematocrit > 46.5%). Older age, Male sex, co-existing viral hepatitis, Dengue Hemorrhagic Fever, Dengue Shock Syndrome, Rhabdomyolysis, Multiple Organ Dysfunction Syndrome were found to be independent risk factors for DAKI. Presence of DAKI was associated with higher mortality and longer hospital stay. Conclusion In our study population, we found a low prevalence of AKI but Mortality was high in patients requiring ICU care and dialysis. Prompt recognition and identification of the at-risk population and administration of appropriate supportive treatment should be aimed to reduce the morbidity and mortality associated with this common and very important tropical disease.