Abstract
Cell competition is a “survival of fittest“ mechanism, through the fitness comparison between less fit ‘loser cells’ and more fit ‘winner cells’ that result in an orchestration of tissue development and homeostasis. Skin provides barrier functions through the maintaining the stratified cell layers using an extremely robust mechanism, yet those exact mechanisms are poorly understood. Previously, we revealed that epidermal homeostasis is regulated by stem cell competition with type XVII collagen (COL17A1), which is a critical component of hemidesmosomes that anchor epidermal stem cells (EpiSCs) to the basement membrane.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
