565: Rate of change of lipid levels in pregnancy associated with first trimester lipid levels and maternal factors

Abstract

sia) were recruited to complete a sleep survey, comprised of the BQ and ESS, and to participate in an overnight sleep evaluation with the Watch-PAT100 (WP100), a wrist-mounted, ambulatory device designed to diagnose SA. The presence of SA was defined as an apnea hypoxiaindex(AHI)of5.InadditiontoevaluatingtheBQandESS, we assessed the performance of a 2 question approach in which patients were considered to be screen positive if their pre-pregnancy BMIwas25andtheyreportedsnoring.TheperformanceoftheBQ, ESS, and a two-question approach (BMI and snoring) were assessed through the use of receiver operating characteristic (ROC) curves. RESULTS: Complete sleep survey and WP100 data was available for 86 women. Area under the curve (AUC) data from the ROC for the BQ, BQESSandthetwo-questionapproachareshownintheTable.The two-question approach performed better than the BQ, the BQ ESS combined, and performed better than the null hypothesis (AUC0.5). The sensitivity and specificity of the BQ were 35% (95% CI 17%, 57%) and 69% (95% CI 55%, 79%), respectively. The twoquestion approach had a much better sensitivity 74% (95% CI 51%, 89%) without sacrificing much specificity 59% (95% CI 46%, 71%). CONCLUSIONS: Standard screening tools for SA are not adequate in pregnancy. A simpler approach, using pre-pregnancy BMI and selfreported snoring, yields better results. Further studies are needed to designandtestthemostappropriatescreeningtoolforSAinpregnant women.