Abstract
Human induced pluripotent stem cell (hiPSC)-derived hair-bearing skin organoids offer exciting new possibilities for modelling diseases like epidermolysis bullosa. These inherited diseases affect 1 in 30,000 people worldwide and result from perturbed expression and/or structure of components of the epidermal-dermal junction, the interface between basal keratinocytes of the epidermis and stroma of the dermis. To establish whether hiPSC-derived skin organoids might be able to capture salient features of epidermolysis bullosa, it is thus important to understand the structure and developmental stage of their epidermal-dermal junction.
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