Abstract
Pharmacologic treatment of headaches during pregnancy can be challenging, particularly when acetaminophen is ineffective. Metoclopramide administered with diphenhydramine (MAD) has been shown to be effective for the treatment of headaches in non-pregnant patients. Both medications are pregnancy category “B,” are low in cost, and generally available. We sought to investigate whether the MAD regimen is effective for the treatment of headaches in pregnant women when acetaminophen alone is ineffective, using codeine as standard for comparison.
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