#5613 ASSESSMENT OF THE PROGRESSION OF CKD TAKING INTO ACCOUNT METABOLIC CHANGES

Abstract

Abstract Background and Aims To study was to study the relationship between the metabolic syndrome and the risk of CKD progression in a representative sample of patients who were hospitalized at the Department of Cardiology and Interventional Cardiology of the Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation. Method In the prospective part of the study, information on demographic characteristics, including age, gender, education, and occupation, was collected from doctor's visits using a standard questionnaire. Metabolic syndrome was defined according to international guidelines in the presence of three or more of the following risk factors: waist circumference >102 cm in men or >88 cm in women; serum triglyceride level ≥1.70 mmol/l; HDL cholesterol level <1.04 mmol/l in men or <1.30 mmol/l in women; BP ≥ 130/85 mm Hg, including achieved; serum glucose level ≥6.11 mmol/l. The criteria for determining the metabolic syndrome were used. Results Demographic characteristics of patients are presented in the table. Mean serum creatinine was similar, but GFR was estimated to be lower among those with metabolic syndrome compared to those without. The percentage of individuals with CKD and elevated serum creatinine was statistically significantly higher among those with metabolic syndrome. It turned out that low HDL cholesterol, elevated plasma glucose and abdominal obesity were statistically significantly associated with the risk of developing C5 CKD and elevated serum creatinine. In addition, there was a significant relationship between the number of metabolic syndrome components and the percentage of C5 CKD or elevated serum creatinine (P<0.015 and P=0.02, respectively). In the multivariate model, patients with 1, 2, 3, and 4 or 5 components of the metabolic syndrome had 1.51; 1.50; 2.13 and 2.72 times higher chances of CKD C5 CKD, respectively, compared to individuals without metabolic syndrome components. Overall, patients with metabolic syndrome had a 64% increase in the odds of CKD compared to the comparison group without metabolic syndrome. Conclusion In the present study, a positive and significant relationship was found between the metabolic syndrome and the risk of C5 CKD in the examined patients. The risk of CKD increased progressively with an increase in the number of components of the metabolic syndrome.