Abstract
(RFLP) analysis. Genotype distribution did not differ significantly between HCC patients (n = 100; AA: 61%; AT 34% and TT: 5%) and healthy controls (n = 127; AA: 50%; AT 41% and TT: 9%). Analysis of genomic DNA isolated from tumorous as well as non-tumorous hepatic tissue revealed identical results. However and noteworthy, carriers of the A-allele had higher GLUT1 expression levels in cancerous hepatic tissue as assessed by quantitative PCR and immunohistochemistry. Conclusion: The SNP Rs710218 is not associated with a higher risk for HCC but for HCC progression, potentially via HIF-1alpha mediated increased GLUT1 expression.
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