Abstract
Contraction-relaxation cycle characteristics and sensitivity to cholinergic stimulation suggest involvement of the Gs-adenylyl cyclase-pathway. The concentration response curves to 5-HT were shifted to higher concentrations by 0.5 nM of the 5-HT4 selective antagonist GR113808, with pEC50-values of 7.62 ± 0.06 (SEM, n = 6) and 7.32 ± 0.06 (SEM, n = 6, p < 0.005), respectively, and the derived pKb value of 9.5 for GR113808 documents involvement of 5-HT4 receptors. Quantitative RT-PCR revealed a 4-fold increase of 5-HT4(b) mRNA expression in ventricles from CHF rat hearts compared to SHAM rat hearts.
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