Abstract
Immune checkpoint blockade (ICB) induces peripheral CD8 T cell proliferation and facilitates mutation-derived neoantigen targets for CD8 T cell antitumor immunity but the kinetics of immune re-invigoration remain poorly understood. Adoptive Cell Therapy (ACT) by ex-vivo T cell expansion has proven effective in high-mutational cancers, yes approaches have largely been restricted to antigen-unspecific T cell expansion. Selective neoantigen-specific CD8 T cell (NART) expansion potentially warrants improved ACT prognosis.
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