Abstract
Adult tissue stem cells (SCs) play an important role in tissue homeostasis and regeneration in multicellular organisms. With aging, these cells decline in their capacities such as regeneration, proliferation, and differentiation, leading to disruption of tissue homeostasis in systemic organs. The senescence-associated secretory phenotype (SASP), that is, senescent cells secrete various inflammatory factors, has been implicated in the promotion of chronic inflammation and organismal aging. However, little is known about the common molecular mechanisms underlying SC aging and their influence on systemic aging.
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