Abstract
A system for applying local hyperthermia employing ultrasonic transducers with annular focusing lenses gave better temperature uniformity in small fibrosarcomas than conventional unfocused transducers. The lenses were designed for ultrasonic frequencies of 3,4,5 and 9 MHz for tumors approximately 6 mm dia. Tests in degassed water indicated that the focusing lenses concentrated approx. 80% of the ultrasonic energy into an annular-shaped focus of 6 mm dia. located at a distance of 3 cm in front of the lens. These transducers were used to heat subcutaneous PARA-7 fibrosarcomas in hamsters. Steady-state temperature measurements indicated temperature gradients within tumors of 0.5–1.0°C when transducers employing annular-focused lenses were used, versus gradients of 2.0–2.3°C with 10 mm dia. unfocused transducers.
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