Abstract
Background: Ultraviolet B (UVB) triggers lupus flares by worsening skin lesions and systemic symptoms, including lupus nephritis. The effects of UVB-induced skin inflammation on kidney injury are not well understood. Neutrophil NETosis has been implicated in lupus. We have reported that UVB induces skin inflammation with recruitment of neutrophils that form NETs and display NET-associated cytokines. We also found that strengthening nuclear envelope integrity by lamin B overexpression decrease NETosis and NET-associated cytokines in the skin of UVB-irradiated lmnb1Tg mice.
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