Abstract

Skin is the third most zinc (Zn)-abundant tissue in the body, In the skin, mast cell (MC) granules are enriched in Zn. Cellular Zn levels are strictly regulated by two groups of Zn transporters: Zn transporters (ZnTs) and Zrt-, Irt-like protein transporters (ZIPs). ZnT expressions were previously determined in the bone-marrow derived MCs (BMMCs). In contrast, little is known about ZIP expressions. Thus, the aim of this study is to determine ZIP expressions in murine MCs. Rodent MCs are categorized into connective tissue MCs (CTMCs) and mucosal MCs (MMCs).

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