55: IVIG to prevent fetal intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia (FNAIT): can we reduce the dose to 0.5 g/kg/wk?

Abstract

The standard and highly effective treatment of pregnancies with FNAIT in which the previous affected child had severe thrombocytopenia but no intracranial hemorrhage (ICH) is weekly intravenous administration of immunoglobulins (IVIG) in a dose of 1 g/kg maternal weight. IVIG is an expensive human multidonor bloodproduct with headaches as main clinical side-effect. Dose-finding studies were never performed, this dose was based on use of IVIG for other diseases. In vitro studies suggested that a lower dose could be just as effective.