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Abstract
Treg-based cellular therapy to suppress graft-directed immunity could reduce the need for life-long immunosuppressive drugs. Challenges include isolating and expanding pure Tregs to clinically relevant numbers while maintaining stable function and phenotype, especially in inflammatory environments. We showed that abundant CD25+FOXP3+ cells can be isolated from discarded pediatric thymuses and expanded to highly suppressive Tregs. Here, we defined stability of expanded thymic Tregs (tTregs) under inflammatory conditions.
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