55 Antimicrobial properties of a novel contactions disinfecting solution, OPTI-FREE EverMoist

Abstract

Purpose: To evaluate the efficacy of a new contact lens disinfecting solution. Method: The efficacy of a new contact lens disinfecting solution with a dual disinfection system was assessed against standard challenge microorganisms and clinical isolates of Acanthamoeba castellanii, Acanthamoeba polyphaga, Staphylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens, Candida albicans, and Fusarium solani using stand-alone microbiological test methodology. Additionally, the efficacy of recently marketed contact lens care solutions, including Revitalens and Biotrue, was tested against standard challenge microorganisms. The stand-alone test is a time kill study designed to qualify individual solutions with a suitable level of antimicrobial activity as contact lens disinfection products. Results: After six hours of disinfection time, the OPTI-FREE EverMoist showed ∼2 logs kill against cysts of A. castellanii ATCC30234 and A. polyphaga ATCC 30871. OPTI-Free EverMoist met the primary Stand-alone criteria with efficacies of more than 4 log reductions for each of the three standard bacteria and each standard yeast and mold. All tested marketed contact lens care solutions showed efficacy against standard challenge microorganisms. Clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens, and Candida albicans were reduced by approximately 4 logs or greater after six hours of exposure to OPTI-FREE EverMoist. Conclusions: OPTI-FREE EverMoist MPDS provides broad spectrum antimicrobial activity against a variety of challenge ATCC and clinical microorganisms. OPTI-FREE EverMoist leverages the proven PolyQuad® and Aldox® dual disinfection system to provide excellent antimicrobial efficacy.